Gastric adenocarcinoma of fundic gland type vs matched normal mucosa

Background: Gastric adenocarcinoma of fundic gland type (GA-FG) is rare, and the mechanisms of carcinogenesis and growth progression have not to be elucidated. Results: Transcriptional profiles of 3 fresh-frozen GA-FG and surrounding normal mucosa were compared. Key features of gene expression analysis suggested that TTF-1/NKX2-1 acts as an important transcription factor in GA-FG. This study will provide insight into the mechanism of development. All samples were obtained prior to resection of target lesions in order to minimize effects of cauterization. Biopsy samples from GA-FG and matched normal mucosa were endoscopically obtained from each patients using endoscopic biopsy forceps. The tissues were collected prospectively with informed consent and the approval of the institutional review board.