BindingDB Entry 50018872: Discovery of Isonicotinamides as Highly Selective, Brain Penetrable, and Orally Active Glycogen Synthase Kinase-3 Inhibitors.

Small molecule binding data for protein Activated CDC42 kinase 1, Aurora kinase A, Aurora kinase B, BDNF/NT-3 growth factors receptor, Casein kinase I isoform delta, Casein kinase II subunit alpha', Cyclin-dependent kinase 2, Cytochrome P450 4B1, Cytoplasmic tyrosine-protein kinase BMX, Glycogen synthase kinase-3 alpha, Glycogen synthase kinase-3 beta, Golgi-associated PDZ and coiled-coil motif-containing protein, High affinity nerve growth factor receptor, Inhibitor of nuclear factor kappa-B kinase subunit beta, Insulin-like growth factor 1 receptor, Interleukin-1 receptor-associated kinase 1, Interleukin-1 receptor-associated kinase 4, MAP kinase-activated protein kinase 2, MAP/microtubule affinity-regulating kinase 3, MAP/microtubule affinity-regulating kinase 4, Macrophage colony-stimulating factor 1 receptor, Mast/stem cell growth factor receptor Kit, Mitogen-activated protein kinase 14, Mitogen-activated protein kinase 8, Non-receptor tyrosine-protein kinase TYK2, Platelet-derived growth factor receptor alpha/beta, Platelet-derived growth factor receptor beta, Potassium voltage-gated channel subfamily H member 2, Protein kinase C theta type, Rho-associated protein kinase 1, Rho-associated protein kinase 2, Ribosomal protein S6 kinase alpha-1, Serine/threonine-protein kinase 33, Serine/threonine-protein kinase MARK1, Serine/threonine-protein kinase MARK2, Serine/threonine-protein kinase pim-1, TRAF2 and NCK-interacting protein kinase, Tau-tubulin kinase 1, Tau-tubulin kinase 2, Tyrosine-protein kinase ABL1, Tyrosine-protein kinase BTK, Tyrosine-protein kinase CSK, Tyrosine-protein kinase Fyn, Tyrosine-protein kinase ITK/TSK, Tyrosine-protein kinase JAK1, Tyrosine-protein kinase JAK2, Tyrosine-protein kinase JAK3, Tyrosine-protein kinase Lck, Tyrosine-protein kinase SYK, Tyrosine-protein kinase Srms, Tyrosine-protein kinase Tec, and Tyrosine-protein kinase ZAP-70, Uniprot O14920, O60674, O75116, P00519, P04629, P05622, P06239, P06241, P07333, P08069, P09619, P10721, P11309, P13584, P19784, P23458, P24941, P26618, P27448, P29597, P41240, P42680, P43403, P43405, P45983, P48730, P49137, P49840, P49841, P51617, P51813, P52333, P97477, Q04759, Q06187, Q07912, Q08881, Q12809, Q13464, Q15418, Q16539, Q16620, Q5TCY1, Q6IQ55, Q7KZI7, Q96GD4, Q96L34, Q9BYT3, Q9H3Y6, Q9HD26, Q9NWZ3, Q9P0L2, and Q9UKE5