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Reactivating p53 to improve therapy in gynecologic cancers

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NIAID Data Ecosystem2026-05-10 收录
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The development of resistance to PARP inhibitors is a major problem and a cause of treatment failures in advanced gynecologic cancers, and we show that adding a p53 reactivator such as HO-3867 enhances the efficacy of PARP inhibitors in p53-mutant cancer models.

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2025-09-19
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