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A safe, effective and adaptable live-attenuated SARS-CoV-2 vaccine to reduce disease and transmission using one-to-stop genome modifications

NIAID Data Ecosystem2026-05-02 收录

病毒疫苗研发

减毒活疫苗评估

数据链接：

https://www.ncbi.nlm.nih.gov/sra/SRP453718 数据链接链接失效反馈

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资源简介：

Development and assessment of novel SARS-CoV-2 live attenuated vaccine (LAV) candidates using the one-to-stop (OTS) approach

应用场景：

创建时间：

2024-06-08

病毒疫苗研发

免疫转录组

Strain 68-1–derived Rhesus Cytomegalovirus (RhCMV) vectors expressing simian immunodeficiency virus (SIV) proteins (RhCMV/SIV) are able to elicit and maintain cellular immune responses that stringentl

NIAID Data Ecosystem50

M. tuberculosis BN attenuated strain

结核疫苗开发

减毒活疫苗评估

We developed a novel profoundly attenuated strain of Mycobacterium tuberculosis using the classic approach of A. Calmette and C. Guerin: serial passaging of virulent mycobacteria in liquid culture med

NIAID Data Ecosystem20

Comparative N‑glycoproteomics Characterization of N‑glycoproteins of H3N8 Viruses Produced in Chicken Embryos versus MDCK Cells

糖蛋白质组学分析

病毒疫苗研发

N-linked glycosylation has been demonstrated to play a critical role in the folding and immunomodulation of influenza virus glycoproteins. Chicken embryos have historically been the predominant produc

NIAID Data Ecosystem10

DataSheet_1_Combination of a Sindbis-SARS-CoV-2 Spike Vaccine and αOX40 Antibody Elicits Protective Immunity Against SARS-CoV-2 Induced Disease and Potentiates Long-Term SARS-CoV-2-Specific Humoral and T-Cell Immunity.pdf

病毒疫苗研发

免疫保护机制评估

The COVID-19 pandemic caused by the coronavirus SARS-CoV-2 is a major global public threat. Currently, a worldwide effort has been mounted to generate billions of effective SARS-CoV-2 vaccine doses to

NIAID Data Ecosystem40

Evaluation of Burkholderia mallei ΔtonB Δhcp1 (CLH001) as a live attenuated vaccine in murine models of glanders and melioidosis

减毒活疫苗评估

鼻疽及类鼻疽病原体研究

BackgroundGlanders caused by Burkholderia mallei is a re-emerging zoonotic disease affecting solipeds and humans. Furthermore, B. mallei is genetically related to B. pseudomallei, which is the causati

Figshare2019-07-15 更新10

A safe, effective and adaptable live-attenuated SARS-CoV-2 vaccine to reduce disease and transmission using one-to-stop genome modifications

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