Activation of STING pathway contributed to cisplatin-induced cardiac dysfunction via promoting the activation of TNF-a-AP-1 signal pathway
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https://www.ncbi.nlm.nih.gov/sra/SRP331829
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资源简介：
In this study, cisplatin activated cGAS-STING signal pathway and deficiency of STING attenuated cisplatin-induced cardiotoxicity in vivo and in vitro. Mechanistically, STING-TNF-a-AP-1 axis contributed to cisplatin-induced cardiotoxicity by triggering cardiomyocyte apoptosis. Overall design: Mice were randomly divided into four groups: saline group (Saline, n=6), cisplatin group (CDDP, n=6), STING-/- group (STING-/-, n=6), STING-/-+cisplatin group (STING-/-+CDDP, n=6). Cisplatin (6 mg/kg) in 0.9% normal saline was administered by intraperitoneal injection on 1th day, 8th day and 15th day as previously reported
创建时间：
2021-09-09
