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A Quantitative, High-Throughput Reverse Genetic Screen Reveals Novel Connections Between pre-mRNA Splicing and 5 and 3 end Transcript Determinants

Alliance of Genome Resources2026-08-01 收录

pre-mRNA剪接

转录末端决定因子

数据链接：

https://www.yeastgenome.org/dataset/GSE34330 数据链接链接失效反馈

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资源简介：

The coding portions of most eukaryotic genes are interrupted by non-coding regions termed introns that must be excised prior to their translation

应用场景：

结直肠癌分子标志物

pre-mRNA剪接

It is widely accepted that most colorectal cancers (CRCs) arise from colorectal adenomas (CRAs), but transcriptomic data characterizing the progression from colorectal normal mucosa to adenoma, and th

NIAID Data Ecosystem10

NF-kappa B p65 regulates snRNA U6 N6-methlyadenosine modification and pre-mRNA alternative splicing by binding to and shuttling METTL16 into nucleus

RNA表观遗传学

pre-mRNA剪接

In the spliceosome, snRNA U6 can form the catalytic core with snRNA U2 to catalyze pre-mRNA alternative splicing. The ACA(43)GAGA box of snRNA U6 is involved in the first step of alternative splicing

NIAID Data Ecosystem10

RNA-seq analysis of the budding yeast ctk1? and rad6? strains and prp45(1-169) ctk1? and prp45(1-169) rad6? double mutant strains

转录调控机制

pre-mRNA剪接

Prp45 is a budding yeast NineTeen-Complex associated factor, which plays a role in pre-mRNA splicing. Because its human ortholog, SNW1/SKIP, is known to functionally and physically interact with facto

NIAID Data Ecosystem00

Two members of a conserved family of nuclear phosphoproteins are involved in pre-mRNA splicing.

pre-mRNA剪接

替代剪接因子

Monoclonal antibody 104 recognizes a subset of amphibian nuclear granules (B-snurposomes) and active sites of RNA polymerase II transcription in vertebrates and invertebrates. Monoclonal antibody 104

PubMed Central1992-02-15 更新10

Pre-mRNA splicing factor atsf1-2 mutant seedlings. Arabidopsis thaliana

pre-mRNA剪接

拟南芥突变体转录组

Analysis of atsf1-2 mutant seedlings for pre-mRNA splicing defect. The atsf1-2 mutant is a homozygous T-DNA insertion line isolated from a SALK line, SALK_062177. Results identify transcripts with alt

NIAID Data Ecosystem10

A Quantitative, High-Throughput Reverse Genetic Screen Reveals Novel Connections Between pre-mRNA Splicing and 5__ and 3__ end Transcript Determinants

资源简介：

相关数据集

A Quantitative, High-Throughput Reverse Genetic Screen Reveals Novel Connections Between pre-mRNA Splicing and 5 and 3 end Transcript Determinants