Human jak1 kinase domain in complex with inhibitor
收藏Protein Data Bank Japan2024-11-06 更新2026-03-21 收录
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Human jak1 kinase domain in complex with inhibitor Descriptor: 1,2-ETHANEDIOL, 2-chloranyl-6-[(3~{S})-3-[(1~{S})-2-cyano-1-[4-(7~{H}-pyrrolo[2,3-d]pyrimidin-4-yl)pyrazol-1-yl]ethyl]pyrrolidin-1-yl]benzenecarbonitrile, Tyrosine-protein kinase JAK1 Authors: Read, J.A, Steuber, H. Deposit date: 2019-08-21 Release date: 2020-04-29 Last modified: 2024-11-06 Method: X-RAY DIFFRACTION (1.85 Å) Cite: Discovery of (2R)-N-[3-[2-[(3-Methoxy-1-methyl-pyrazol-4-yl)amino]pyrimidin-4-yl]-1H-indol-7-yl]-2-(4-methylpiperazin-1-yl)propenamide (AZD4205) as a Potent and Selective Janus Kinase 1 Inhibitor. J.Med.Chem., 63, 2020
创建时间：
2019-08-21
