Characteristics of patients with chronic Chagas' disease Cardiomyopathy.

aF: female, M: male.
bPatient's heart failure was classified according to New York Heart Association (NYHA) Functional Classification. Class I: Patients with cardiac disease with slight functional alterations but resulting in no limitation of ordinary physical activity; however, elevated activity causes symptoms, such as fatigue, palpitation, or dyspnea (shortness of breath); Class II: Patients with cardiac disease resulting in slight limitation of physical activity; comfortable at rest, but ordinary physical activity results in symptoms; Class III: Patients with cardiac disease resulting in marked limitation of physical activity; comfortable at rest, but less than ordinary activity causes symptoms; Class IV: Patients with cardiac disease resulting in marked limitation of physical activity, unable to carry out any physical activity without discomfort; symptoms of cardiac insufficiency at rest.
Patients with cardiac disease without any functional alteration were classified as Class 0.
cThe level of antibodies directed to T. cruzi lysate was determined by in-house ELISA as described upon Methods.
dT cruzi lineage was analyzed by TSSA recognition as described upon Methods. Results are shown in Figure S1. ND: not detected.