Gene expression profile at single cell level of testicular cells from young and aged mice. Gene expression profile at single cell level of testicular cells from young and aged mice

Testicular aging commonly leads to testosterone deficiency and impaired spermatogenesis, yet the underlying mechanisms remain elusive. Here, we performed a comprehensive scRNA-seq analysis of senescence landscapes in mice testes during aging. Overall design: We harvested testicular tissue from 2-month-old and 24-month-old mice, isolated the stroma cells, and then performed single-cell sequencing