RNA Sequencing of Liver Samples from UM-HET3 Mice Exposed to Various Compounds from the ITP Study

This dataset contains liver gene expression profiles of aged UM-HET3 male and female mice subjected to long-term treatment with various compounds from ITP studies, along with age-matched and young control mice of the same strain. It is part of a broader dataset used to identify gene expression signatures of aging, mortality, and lifespan, as well as to develop rodent and multi-species transcriptomic clocks of chronological age and expected mortality. Overall design: Male and female UM-HET3 mice were treated with various compounds in food as part of the ITP program until sacrifice at 22 months. Canagliflozin group: 7 biological replicates per sex; other compounds: 3 biological replicates per sex; old (22-month-old) control group: 24 biological replicates per sex; young (4-6-month-old) control group: 6 biological replicates per sex.