Data Sheet 1_Association between CYP1A1 gene polymorphisms at rs4646903 and rs1048943 loci and susceptibility to prostate cancer: meta-analysis.zip

ObjectiveTo evaluate the associations between C allele of CYP1A1 rs4646903 (T>C) and G allele of CYP1A1 rs1048943 (A>G) polymorphisms and prostate cancer (PCa) susceptibility under different genetic models.
MethodsWe systematically searched PubMed, EMBASE, CNKI, and Wanfang databases from inception to December 31, 2024. Eligible case–control studies were selected. Study quality was assessed using the Newcastle–Ottawa Scale (NOS). Meta-analyses were performed using RevMan 5.3 software.
ResultsFifteen studies for rs4646903 and 14 studies for rs1048943 were included. For rs4646903 (T>C): The dominant model (CC+CT vs TT) showed that carrying the C allele was associated with increased PCa risk (OR = 1.39, 95%CI: 1.13–1.71, P = 0.002). For rs1048943 (A>G): Carrying the G allele was associated with decreased PCa risk in multiple models: allele model (G vs A: OR = 0.80, 95%CI: 0.71–0.90, P<0.001); homozygous model (GG vs AA: OR = 0.56, 95%CI: 0.42–0.76, P<0.001); dominant model (GA+GG vs AA: OR = 0.72, 95%CI: 0.55–0.94, P = 0.02); recessive model (GG vs GA+AA: OR = 0.78, 95%CI: 0.62–0.99, P = 0.04).
ConclusionThe C allele of CYP1A1 rs4646903 may increase PCa risk under the dominant model. The G allele of CYP1A1 rs1048943 may reduce PCa risk across multiple genetic models.