Polycomb complexes in skin epithelium development III
收藏NIAID Data Ecosystem2026-03-14 收录
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https://www.ncbi.nlm.nih.gov/sra/SRP284319
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资源简介：
Polycomb group (PcG) proteins are essential epigenetic transcriptional regulators. Traditionally, PcG proteins function as two multi-subunit complexes, Polycomb repressive complex 1 (PRC1) and PRC2, which largely overlap in their genomic binding and cooperate to establish repressive chromatin domains demarcated by H2AK119ub and H3K27me3. Here, using the developing skin epidermis as a paradigm, we uncovered a functional redundancy between Polycomb complexes in the repression of unwanted non-lineage genes. Overall design: Newborn mouse epidermal cells were purified from Eed;Ring1a/b triple knock out and control mice. RNA from the sorted cells was analyzed by RNA-seq.
创建时间：
2023-01-02
