Gene expression modification in lungs of rats exposed to DQ-12 by endotracheal instillation

In this work we study the pulmonary toxicological properties of cristalline silica DQ-12 using molecular toxicological approache. For this, we exposed Sprague Dawley rats by endotracheal instillation. Lung samples have been collected up to 180 days after the end of exposure and transcriptomics analysis were performed.本研究采用分子毒理学方法，探究结晶型二氧化硅DQ-12（crystalline silica DQ-12）的肺部毒理学特性。为此，通过气管内滴注（endotracheal instillation）方式对斯普拉格-道利大鼠（Sprague Dawley rats）实施染毒。于染毒结束后最长180天内采集肺组织样本，并开展转录组学分析（transcriptomics analysis）。