NEIL3 recognizes and binds to 5-guanidinohydantoin (Gh) in telomeric DNA

NEIL3, a DNA glycosylase of the NEIL family, recognizes and binds to damaged telomeric DNA containing 5-guanidinohydantoin (Gh). Binding of NEIL3 to telomeric DNA is facilitated by interaction of NEIL3 with TRF1, a component of the telomeric shelterin complex (Zhou et al. 2017).

NEIL3，作为NEIL家族的DNA糖苷酶，能够识别并结合含有5-胍基脒（Gh）的损伤性端粒DNA。NEIL3与端粒庇护复合体（telomeric shelterin complex）的组成部分TRF1相互作用，从而促进了NEIL3与端粒DNA的结合（Zhou等人，2017年）。