Association between the CNR1 1359 G/A (p.Thr453Thr) genotype and CD characteristics.

1Disease behavior was defined according to the Montreal classification [28]. A stricturing disease phenotype was defined as presence of stenosis without penetrating disease. The diagnosis of stenosis was made surgically, endoscopically, or radiologically (using MRI enteroclysis).2Immunosuppressive agents included azathioprine, 6-mercaptopurine, 6-thioguanin, methotrexate, and/or infliximab.3Extraintestinal manifestations were defined as one or more of the following IBD-related diseases: non-medication-induced arthropathies (e.g., ankylosing spondylitis, sacroileitis, peripheral arthritis), eye involvement (e.g., episcleritis and/or iritis/uveitis), skin involvement (e.g., erythema nodosum and pyoderma gangrenosum), non-medication-induced biliary disease (e.g., sclerosing cholangitis).4Only surgery related to CD-specific problems (e.g., fistulectomy, colectomy, ileostomy) was included.