Immune-associated orthologous genes across primates

The immune system acts as a bridge between pathogenic microorganisms and
their hosts. Despite its significance, to date, the evolutionary
mechanisms of immune system complexity are largely not well understood in
primates. In this study, we applied a newly developed strategy (TOGA
pipeline) to generate a robust one-to-one orthologous gene catalog
including 15,057 protein-coding genes accounting for ~78% of the annotated
gene set of the human genome (hg38) and representing ~ 28.9 Mbp (coding
sequence), across 50 primate species and two closest outgroups (Malayan
flying lemur and Chinese tree shrew). Deeply, to obtain a comprehensive
immune-associated gene catalog across primates, we investigated six known
public datasets (GO, KEGG, InnateDB, Immport, HPO and Enard et al., 2016)
and found that 4,744 of 5,635 immune-associated genes were covered in our
constructed one-to-one orthologous catalog across 52 species.