DNA damage response (only ATM dependent)

This is one of two pathways that deal with DNA damage. It has two central gene products (ATM and TP53) which are connected with the [[Pathway:WP707|other DNA damage response pathway]]. In this pathway there is only one source of DNA damage induction, since most DNA damage induction sources and their involvement are mentioned in the [[Pathway:WP707|first DNA damage response pathway]]. If it is not mentioned differently, the processes take place in the cell cytoplasm. The purpose of this pathway is to report more gene products and cell condition changes through the DNA damage response pathway and at the same time keep them clearly arranged. Proteins on this pathway have targeted assays available via the [https://assays.cancer.gov/available_assays?wp_id=WP710 CPTAC Assay Portal]

此为处理DNA损伤的两大途径之一。该途径包含两个核心基因产物（ATM和TP53），它们与（[[Pathway:WP707|其他DNA损伤响应途径]]）相联系。在此途径中，DNA损伤诱导的来源单一，因为大多数DNA损伤诱导来源及其参与情况已在（[[Pathway:WP707|第一DNA损伤响应途径]]）中提及。除非另有说明，否则相关过程均在细胞质中进行。此途径的目的是通过DNA损伤响应途径报告更多基因产物及细胞状态的变化，同时确保其条理清晰。该途径上的蛋白质具有通过[CPTAC检测门户](https://assays.cancer.gov/available_assays?wp_id=WP710)进行目标检测的可用方法。