The Genome and Transcriptome of Fibrolamellar Hepatocellular Carcinoma

Fibrolamellar hepatocellular carcinoma (FL-HCC) is a rare liver tumor primarily affecting adolescents and young adults. Little is known of the molecular pathogenesis. To characterize the disease we performed RNA sequencing and whole genome sequencing on FL-HCC tumors and adjacent normal tissue. The results demonstrate few consistent differences on the chromosomal level and many hundreds of alterations in the expression of RNA transcripts.]]>
Patients of any sex or age with histologically verified pure fibrolamellar hepatocellular carcinoma and adjacent normal liver parenchyma were included.]]>
Specimens were collected from hospitals performing primary resections as well as samples collected by the National Development and Research Institute.]]>