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Effect of miR-106b~25 in mouse spermatogenesis and male fertility

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We investigated the miRNA cluster miR-106b~25 as potential candidate causing male infertility. We analyzed single and double KO mice. Single KO show deregulation of multiple molecular pathways and disrupted early spermatogenesis, but retain fertility. Double KO show severely disrupted testicular histology and significantly reduced fertility.

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