RNA sequencing of BT474 cells treated with trastuzumab or trastuzumab + pertuzumab and BT474-derived cells resistant to trastuzumab or trastuzumab + pertuzumab
收藏NIAID Data Ecosystem2026-03-11 收录
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https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE121105
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资源简介：
We sequenced untreated BT474 cells, BT474 cells treated for three days with trastuzumab or trastuzumab + pertuzumab, as well as two BT474-derived trastuzumab-resistant pools and two BT474-derived trastuzumab + pertuzumab resistant pools. Resistant pools were generated by culturing BT474 cells in gradually increasing doses of trastuzumab and trastuzumab + pertuzumab over the course of several months and continually maintained in drug. Examination of mRNA profiles of 1) BT474 cells 2) BT474 cells treated for three days with trastuzumab 3) BT474 cells treated for three days with trastuzumab + pertuzumab 4) two trastuzumab-resistant cell pools 5) two trastuzumab+pertuzumab resistant cell pools
创建时间：
2020-03-31
