Epigenetic activation of SOX11 is associated with recurrence and progression of DCIS to invasive breast cancer [Nanostring]

Epigenetic activation of SOX11 is associated with recurrence and progression of DCIS to invasive breast cancer. SOX11 and its epigenetic regulators can be developed as prognostic markers for DCIS patients with recurrence risk independent of traditional clinical and pathologic characteristics. NanoString nCounter analysis system was performed using a custom codeset consisting of 53 genes-of-interest plus 5 housekeeping genes commonly identified from public available DCIS gene expression datasets and correlated with recurrence events using Kessler's breast cancer dataset.