Cyp8b1

ENCODES a protein that exhibits sterol 12-alpha-hydroxylase activity; INVOLVED IN response to cholesterol; response to nutrient levels; bile acid biosynthetic process (ortholog); PARTICIPATES IN bile acid biosynthetic pathway; cerebrotendinous xanthomatosis pathway; congenital bile acid synthesis defect pathway; ASSOCIATED WITH extrahepatic cholestasis; Chemical and Drug Induced Liver Injury (ortholog); cholestasis (ortholog); FOUND IN endoplasmic reticulum membrane (inferred); INTERACTS WITH (+)-schisandrin B; 1,3,7,9-tetramethyluric acid; 1-(3-(trifluoromethyl)phenyl)piperazine

编码一种展现类固醇12-α-羟化酶活性的蛋白质；参与胆固醇响应、营养水平响应及胆汁酸生物合成过程（同源）；在胆汁酸生物合成途径、 cerebrotendinous xanthomatosis 途径、先天性胆汁酸合成缺陷途径中发挥作用；与肝外胆汁淤积、化学和药物诱导的肝脏损伤（同源）、胆汁淤积（同源）相关；存在于内质网膜（推断）；与 (+)-schisandrin B、1,3,7,9-四甲基尿酸、1-(3-(三氟甲基)苯基)哌嗪相互作用。