Figure S1 - Elevated Alpha-Synuclein Impairs Innate Immune Cell Function and Provides a Potential Peripheral Biomarker for Parkinson's Disease

Microglia isolated from line 26/syn null or α-syn null littermates were stimulated with LPS in the presence or absence of Brefeldin A. Tissue culture supernatant was assessed for TNF-α production by ELISA (n = 2; 5 pups/GT/expt +/− s.e.m *p≤0.001 when α-syn TG samples were compared with non-TG). (EPS)