Short and Scalable Total Synthesis of Myrioneuron Alkaloids (±)-α,β-Myrifabral A and B

The
first total synthesis of the Myrioneuron alkaloids
(±)-α,β-myrifabral A and B has been accomplished
in only four steps from conveniently available starting materials.
This short synthesis relied on the use of a key tandem Mannich/amidation
reaction to rapidly construct the core framework and two carbon stereocenters.
The synthetic route allows for large scale preparation of these promising
natural products against the hepatitis C virus (HCV).