Distribution of the most frequent CFTR mutations detected in CF patients from Poland, compared with Central and Southeastern European populations.

Legend: Data are given in %. a non-INNOLiPA mutations are in bold, and a novel mutation is underlined; b very close to the earlier estimate of 54% based on a much smaller study group of PL patients [7]; c only selected segments of the gene have been screened; d frequency significantly higher or e lower than in Polish cohort (p<0.005, Pearsons’s chi square); f[5]; NA– not analyzed/not available; Poland (mostly Southern and Western Poland; this study); Czech Republic [21]; Slovakia (based on [21]); Germany [22]; Lithuania [23]; Western Ukraine [24]; East Hungary [25]; Romania [26]; Bulgaria [27]; Serbia [28]; Greece [29].