Sensitivity analyses: effects of systematic errors in model inputs.

aDefault values were as follows: percent understaging, 0%; size at clinical diagnosis (dx) (BRCA1) (see Table S3, reference [35]); size at clinical diagnosis (normal risk), 8 cm diameter; duration of occult period, 5.1 y (see Results); percent progressive tumors, 100%.bValues shown in first row were used as inputs into the model shown in Figure 1. All other variables were fixed at default values (see footnote a).cValues indicate the size of tumor (diameter) that an early detection test must detect in order to achieve 50% early detection sensitivity given the modified model input specified in the relevant column header.dValues shown indicate the size of tumor (diameter) that an early detection test must detect in order to achieve a 50% reduction in 5-y mortality given the modified model input specified in the relevant column header.