Household laundry detergents disrupt barrier integrity and induce inflammation in mouse and human skin

To investigate the effect of household detergents on the mouse skin barrier, we treated mouse's back skin with two household detergents (A and B) and collected the treated skin 24 hours after the application. We then performed gene expression profiling analysis using data obtained from RNA-seq of mouse skin treated with detergent A, detergent B, and PBS. We performed gene expression profiling analysis using data obtained from RNA-seq of the skin biopsy at 24 hours after the application. Overall design: Comparative gene expression profiling analysis of RNA-seq data for detergent A treated skin and detergent B treated skin compared with PBS treated skin.