Germline-targeting SIVcpz Env in B cell responses in infected rhesus macaques.

Eliciting broadly neutralizing antibodies (bnAbs) remains a major goal of HIV-1 vaccine research.Previously, we showed that a soluble chimpanzee SIV Envelope (Env) trimer, MT145K, boundseveral human V2-apex bnAb precursors and stimulated an appropriate response in V2-apex bnAbprecursor-expressing knock-in mouse. Here, we tested the immunogenicity of three MT145 variants(MT145, MT145K, MT145.dV5) as simian-chimpanzee immunodeficiency viruses (SCIVs) in rhesusmacaques (RMs). Sequencing data of antibody heavy chain repertoires (IgM and IgG) were generated at multiple time points.