Crystal Structure of Dipeptidyl Peptidase IV (DPP4, DPP-IV, CD26) in Complex with Fab + sitagliptin
收藏Protein Data Bank Japan2024-11-06 更新2026-03-21 收录
下载链接：
https://pdbj.org/mine/summary/4ffw
下载链接
链接失效反馈官方服务：
资源简介：
Crystal Structure of Dipeptidyl Peptidase IV (DPP4, DPP-IV, CD26) in Complex with Fab + sitagliptin Descriptor: (2R)-4-OXO-4-[3-(TRIFLUOROMETHYL)-5,6-DIHYDRO[1,2,4]TRIAZOLO[4,3-A]PYRAZIN-7(8H)-YL]-1-(2,4,5-TRIFLUOROPHENYL)BUTAN-2-A MINE, Dipeptidyl peptidase 4, Fab heavy chain, ... Authors: Wang, Z, Sudom, A, Walker, N.P, Min, X. Deposit date: 2012-06-01 Release date: 2012-12-12 Last modified: 2024-11-06 Method: X-RAY DIFFRACTION (2.9 Å) Cite: An Inhibitory Antibody Against DPP IV Improves Glucose Tolerance in vivo - Validation of Large Molecule Approach for DPP IV Inhibition To be published
二肽基肽酶IV（Dipeptidyl Peptidase IV, DPP4, DPP-IV, CD26）与Fab片段及西格列汀（sitagliptin）复合物的晶体结构
描述项：(2R)-4-氧代-4-[3-(三氟甲基)-5,6-二氢[1,2,4]三唑并[4,3-a]吡嗪-7(8H)-基]-1-(2,4,5-三氟苯基)丁-2-胺、二肽基肽酶4、Fab重链……
作者：Wang, Z、Sudom, A、Walker, N.P、Min, X
提交日期：2012-06-01
发布日期：2012-12-12
最后修改日期：2024-11-06
检测方法：X射线衍射（X-RAY DIFFRACTION，分辨率2.9 Å）
引用文献：《靶向DPP IV的抑制性抗体可在体内改善葡萄糖耐受——DPP IV抑制大分子疗法的验证》（待发表）
创建时间：
2012-06-01
