Crystal structure of EGFR kinase domain in complex with compound 4c

Crystal structure of EGFR kinase domain in complex with compound 4c Descriptor: 4-(dimethylamino)-N-[3-(4-{[(1S)-2-hydroxy-1-phenylethyl]amino}-6-phenylfuro[2,3-d]pyrimidin-5-yl)phenyl]butanamide, Epidermal growth factor receptor Authors: Peng, Y.H, Wu, J.S. Deposit date: 2013-03-22 Release date: 2013-06-19 Last modified: 2023-11-08 Method: X-RAY DIFFRACTION (2.8 Å) Cite: Protein Kinase Inhibitor Design by Targeting the Asp-Phe-Gly (DFG) Motif: The Role of the DFG Motif in the Design of Epidermal Growth Factor Receptor Inhibitors J.Med.Chem., 56, 2013化合物4c结合的表皮生长因子受体（EGFR）激酶域晶体结构 描述项：4-(二甲氨基)-N-[3-(4-{[(1S)-2-羟基-1-苯乙基]氨基}-6-苯基呋喃并[2,3-d]嘧啶-5-基)苯基]丁酰胺，靶标为表皮生长因子受体 作者：Peng Y.H.、Wu J.S. 入库日期：2013-03-22 发布日期：2013-06-19 最后更新：2023-11-08 检测方法：X射线衍射（分辨率2.8埃） 引用文献：《以靶向天冬氨酸-苯丙氨酸-甘氨酸（Asp-Phe-Gly，DFG）基序设计蛋白激酶抑制剂：DFG基序在表皮生长因子受体抑制剂设计中的作用》，《J. Med. Chem.》，第56卷，2013年