Effects of excessive iodine intake on brain development

To evaluate the impact of perinatal iodine excess intake on neurodevelopment, we conducted a gene expression profiling assessment using microarray technology. This evaluation was performed on the hippocampus of adult female offspring mice from both the 20-fold iodine intake group and the control group, which exhibited statistically significant differences in learning and memory-related behavioral experiments. Despite the observed behavioral differences, no significant differences were found in the gene expression profiles. Total RNA was extracted from dorsal hippocampus after behavioral test battery. Total RNA from female control group and 20-fold iodine intake group were used for microarray.