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Distinct perturbation of the translatome by the anti-diabetic drug metformin

ChEBI2012-05-20 更新2026-07-21 收录

药物机制研究

翻译组分析

数据链接：

https://www.ebi.ac.uk/biostudies/ArrayExpress/studies/E-GEOD-36847 数据链接链接失效反馈

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资源简介：

Distinct perturbation of the translatome by the anti-diabetic drug metformin

应用场景：

创建时间：

2012-05-20

基因本体富集分析

药物机制研究

This analysis was performed using the DAVID program (see MM). Count indicates the number of genes belonging to the indicated gene ontology biological processes that we found regulated by a factor 2; %

NIAID Data Ecosystem60

Description of total RNA-seq and polyribosomal RNA-seq libraries.

转录组测序

翻译组分析

(DOCX)

NIAID Data Ecosystem60

The IC 50 of the inhibitory effect of tylophora alkaloids on NF-κB, AP-1, and CRE signalging pathways in HepG2 and HEK-293 cells.

信号通路抑制

药物机制研究

Values are means ± SD of at least three experiments, with each data point done in triplicate. The IC50 concentrations of these compounds are significantly different (p<0.05) from each other in between

NIAID Data Ecosystem40

CDK4/6 inhibitors induce repication stress to cause long-term cell cycle withdrawal

细胞周期调控

药物机制研究

CDK4/6 inhibitors arrest the cell cycle in G1-phase. They are licenced to treat breast cancer and are also undergoing clinical trials against a range of other tumour types. To facilitate these efforts

NIAID Data Ecosystem60

C57bl/6 liver Transcriptome. Mus musculus

疾病转录组学

药物机制研究

there are few reports on rhein effects on liver diseases. Therefore, this study aims to investigate these effects and underlying mechanisms.

NIAID Data Ecosystem50