Statistical analysis of exploratory activity.

The numbers displayed in table 2 indicate the P-values for each of the parameters analysed (genotype of mice, age of mice and time in the activity cages), with significant P-values highlighted for ease of interpretation. Mice in activity cages are shown to behave differently with respect to measures of exploratory behaviour (as determined by measuring activity, mobility and rearing) over a period of one hour (Time). Wild-type and R6/2 mice exhibit reproducible differences in measures of exploratory behaviour with R6/2 mice developing a progressive hypoactivity that becomes significant at older ages as demonstrated by decreased activity and mobility in addition to decreased rearing behaviour (R6/2 genotype and R6/2 genotype*time). Hdac7 reduction does not influence the behaviour of mice for any parameter assessed (Hdac 7 genotype and Hdac7*time) and furthermore, there appears no interaction between Hdac7 and R6/2 genotypes (R6/2*Hdac7 and R6/2*Hdac7*time).