Skin microbiome in small and large plaque parapsoriasis

The etiology for small plaque and large plaque parapsoriasis, the latter sometimes progressing to mycosis fungoides, is not known. We searched for eventual changes in the skin microbiome of parapsoriasis lesions compared to intact skin. Skin swab microbiome specimens were taken of the parapsoriasis lesions of 13 patients (6 with small plaque parapsoriasis, 7 with large plaque parapsoriasis). Control samples were collected from the contralateral body side of each patient. The microbiota were characterized by sequencing the V1-V3 region of the 16S riboso-mal RNA bacterial genes on the Illumina MiSeq platform.