Uncleaved Pink1 accumulates in damaged mitochondria

On damaged mitochondria that have lost their membrane potential, however, PINK1 cleavage is inhibited, leading to high PINK1 protein accumulation on the inner leaf of the mitochondrial outer membrane (MOM) of dysfunctional mitochondria. Full-length mitochondrial PINK1 is the active form in the PINK1/Parkin pathway.

然而，在膜电位丧失的受损线粒体中，PINK1的裂解受到抑制，导致高水平的PINK1蛋白在功能失调线粒体外膜（MOM）的内叶积累。全长线粒体PINK1是该PINK1/Parkin通路中的活性形式。