ALDH3A2-2 oxidizes pristanal to pristanate

Peroxisomal ALDH3A2-2 (fatty aldehyde dehydrogenase family 3 member A2, isoform 2) catalyzes the NAD-dependent dehydrogenation of pristanal to form pristanate (Jansen et al. 2001; Kelson et al. 1997; Rizzo et al. 2001). Structural studies suggest that the enzyme is a homodimer (Keller et al. 2010), and expression studies of the homologous mouse proteins in cultured cells indicate that ALDH3A2 isoform 2 is localized to peroxisomes while isoform 1 is localized to the endoplasmic reticulum (Ashibe et al. 2007).

过氧化物酶体醛脱氢酶3A2-2（脂肪酸醛脱氢酶家族3成员A2，异构体2）催化NAD依赖的丙酮醛的脱氢反应，生成丙酮酸（Jansen等，2001；Kelson等，1997；Rizzo等，2001）。结构研究表明，该酶为同源二聚体（Keller等，2010），而同源小鼠蛋白在培养细胞中的表达研究表明，ALDH3A2异构体2定位于过氧化物酶体，而异构体1则定位于内质网（Ashibe等，2007）。