To explore the mechanism of NHDC improving insulin resistance of diabetic zebrafish based on intestinal bacteria

Neohesperidin dihydrochalcone (NHDC), a bicyclic flavonoid compound, has many important physiological functions. Intestinal microbial community composition is closely related to metabolic diseases such as diabetes. Studies have confirmed that the intestinal flora of patients with diabetes is dysfunctional, and the diversity and abundance of intestinal flora are decreased. In this study, 16S rDNA sequencing method was used to analyze the intestinal microbial community structure of each zebrafish treatment group, compare the intestinal community structure and diversity, explore whether NHDC can alleviate insulin resistance by regulating intestinal microecology, and identify the key changing bacteria.