Primordially conserved principles of IgT in mucosal pathogen control and microbiota homeostasis

Teleost fish a mucosa-associated lymphoid tissue (MALT) that lacks organized structures. Teleost mucosal surfaces are colonized by a diverse microbiota and fish produce secretory Igs (sIgs) which are able to coat commensal bacteria in the gut, gills, skin and nose. Similar to mammals, perturbance of the host immune system can result in states of dysbiosis