botC:GT1b internalized from target cell plasma membrane to synaptic vesicle membrane

Synaptic vesicles re-form rapidly after exocytosis, carrying vesicle membrane proteins that had been exposed on the cell surface by exocytosis back into the cell (Sudhoff 2004). The botulinum toxin type C disulfide-bonded heavy chain - light chain heterodimer (botC HC:LC) bound to ganglioside GT1b is inferred to be taken up as well, delivering it to the re-formed synaptic vesicle.

突触囊泡在胞吐作用后能够迅速重组，携带着通过胞吐作用暴露于细胞表面的囊泡膜蛋白重新进入细胞（Sudhoff 2004）。据此推断，与神经节苷脂GT1b结合的肉毒毒素C型二硫键连接的重链-轻链异源二聚体（botC HC:LC）亦被摄取，并递送至重新形成的突触囊泡中。