A three component mix of thioredoxin-L2 antigens elicits broadly neutralizing responses against oncogenic human papillomaviruses.
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The epitope sequence was provided in Rubio et al. Vaccine 2009 27:1949 [PMID 19368776]. Immunization with the Trx-HPV16 L2 (20-38)3 construct protected nearly all mice against heterologous challenge with HPV31 pseudovirions in a cervicovaginal mouse model.
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2014-01-01
