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M. tuberculosis meets European Lead Factory: identification and structural characterization of novel Rv0183 inhibitors using X-ray crystallography: ELF5

NIAID Data Ecosystem2026-05-10 收录

抗结核药物发现

晶体学结构解析

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M. tuberculosis meets European Lead Factory: identification and structural characterization of novel Rv0183 inhibitors using X-ray crystallography: ELF5

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创建时间：

2025-10-29

抗结核药物发现

X射线晶体学药物设计

Thymidylate synthase X (ThyX) represents an attractive target for tuberculosis drug discovery. Herein, we selected 16 compounds through a virtual screening approach. We solved the first X-ray crystal

NIAID Data Ecosystem50

Hen Egg White Lysozyme co-crystallized with cis-Ru(DMSO)4Cl2

金属药物-蛋白质相互作用

晶体学结构解析

Hen Egg White Lysozyme co-crystallized with cis-Ru(DMSO)4Cl2 Descriptor: ACETATE ION, CHLORIDE ION, Lysozyme C, ... Authors: Kurpiewska, K, Halajko, P, Lewinski, K. Deposit date: 2016-09-14 Release da

Protein Data Bank Japan2024-10-23 更新20

Identification of a Series Containing a Pentafluorophenyl Moiety That Targets Pks13 to Inhibit Growth of Mycobacterium tuberculosis

抗结核药物发现

Pks13抑制剂优化

Although not currently in the infectious disease spotlight, there is still a pressing need for new agents to treat tuberculosis caused by Mycobacterium tuberculosis. As there is an ever-increasing amo

NIAID Data Ecosystem00

Targeting Mycobacterium tuberculosis Biotin Protein Ligase (MtBPL) with Nucleoside-Based Bisubstrate Adenylation Inhibitors

抗结核药物发现

核苷类酶抑制剂

Mycobacterium tuberculosis (Mtb), responsible for both latent and symptomatic tuberculosis (TB), remains the second leading cause of mortality among infectious diseases worldwide. Mycobacterial biotin

NIAID Data Ecosystem30

Table_1_Biological Profiling Enables Rapid Mechanistic Classification of Phenotypic Screening Hits and Identification of KatG Activation-Dependent Pyridine Carboxamide Prodrugs With Activity Against Mycobacterium tuberculosis.docx

抗结核药物发现

前药机制解析

Compounds with novel modes of action are urgently needed to develop effective combination therapies for the treatment of tuberculosis. In this study, a series of compounds was evaluated for activity a

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M. tuberculosis meets European Lead Factory: identification and structural characterization of novel Rv0183 inhibitors using X-ray crystallography: ELF5

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