A single-cell atlas of the peripheral immune response in patients with HFRS.

Hemorrhagic Fever with Renal Syndrome (HFRS) is a regional infectious disease of epidemic potential caused by the Hantaan Virus (HTNV).The studies on immunological responses during HTNV infection have continuously been performed. During HTNV infection, lymphocytes are following a tightly controlled genetic programme.The pathological changes of PBMCs also occured during HTNV infection. We used single cell RNA sequencing to detail the cellular components and gene expression profiles of PBMCs underlying HTNV infection. Overall design: The PBMCs were isolated from the whole blood of HFRS patients. We selected PBMCs from acute phase of HFRS patients and performed scRNA seq.