AR-V7 targets the oncogenic genes in castration resistant prostate cancer. [ChIP]
收藏NIAID Data Ecosystem2026-03-12 收录
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https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE122922
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资源简介：
To elucidate the AR-V7 role, we performed ChIP-seq on H3K4me1, H3K4me3, H3K27ac, and AR antibody recognizing the N-terminus of AR and AR splice variants (AR-Vs) using LNCaP and LNCaP95 cells. We showed 399 AR-V7 targeted regions in LNCaP95, most of the AR-V7 target regions could be commonly activated by hormone stimulated AR. However, 22 regions were identified as AR-V7 specific regions. In addition, we show here that AR-V7 can transcript in the ligand independent manner in LNCaP95, unlike LNCaP. We identified the AR-V7 target gene contributing to the CRPC progression. 1) Examination of AR and AR-V7 target regions and 2 different histone modifications in LNCaP or LNCaP95 cells. 2) Examination of different histone modifications in shRNA-mediated knockdown LNCaP95 cells.
创建时间：
2020-11-02
