Gene expressions of CD4+ T cells from patients with rheumatoid arthritis in each developmental stages. Homo sapiens

The development of T cells has been characterized as taking place over three stages: naïve (Tn), central memory (Tcm), and effector memory (Tem) cells. Recently, stem cell memory T cells (Tscm) were found to be the least-developed memory subset. We performed detailed analysis of the gene expression of human CD4+ T cells from patients with rheumatoid arthritis with clear distinction of the Tn, Tscm, Tcm, and Tem stages. Overall design: We sorted Tn, Tscm, Tcm, and Tem CD4+ T cells from the peripheral blood of six patients with rheumatoid arthritis to see the differences of gene expression between each developmental stage.