Effects of treatment with mDEF201 and cidofovir on survival of mice from a vaccinia virus (WR strain) respiratory infection.

amDEF201 and empty vector are PFU/mouse doses, whereas the dose of cidofovir is mg/kg/day. mDEF201, the Ad-5 empty vector, and the placebo groups were given single intranasal treatments. Cidofovir was administered by intraperitoneal route once a day for two days. For consistency with the other groups, the cidofovir group also received saline intranasally at −24 h.bRelative to intranasal virus exposure (1×105 PFU).cMean day of death of animals that died on or before day 21 of the infection.*P**P***P