Oocyte-specific knockout of eIF2 subunits causes apoptosis of mouse oocytes within the early growing follicles via mitochondrial dysfunctions and DNA damage

Mutations in several translation initiation factors are closely associated with premature ovarian insufficiency (POI). In this study, we demonstrated that the conditional knockout of eukaryotic initiation factor 2 (eIF2) subunits Eif2s1 and 2 in mouse oocytes caused oocyte apoptosis within the early growing follicles. Subsequent research indicated that the Mutations in several translation initiation factors are closely associated with premature ovarian insufficiency (POI).