scRNAseq of TAZ-CAMTA1 expressing endothelial cells in vivo. scRNAseq of TAZ-CAMTA1 expressing endothelial cells in vivo

TAZ-CAMTA1 is a defining genetic aberration in the vascular cancer epithelioid hemangioendothelioma. We generated a novel transgenic mouse that expresses TAZ-CAMTA1 in endothelial cells. These mice develop vascular tumors in the lung and die by average on day 40. We isolated GFP + endothelial cells from three five-week old TRE-TAZ-CAMTA1;Cdh5-tTA;TRE-GFP mice and subjected these endothelial cells to scRNA-seq via the 10X genomics platform Overall design: scRNA seq of GFP+ cells from 5 week-old TRE-GFP;TRE-TAZ-CAMTA1;Cdh5-tTA mice