Crystal Structure of PI3Kalpha in complex with fragments 5 and 21
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Crystal Structure of PI3Kalpha in complex with fragments 5 and 21 Descriptor: 1H-benzimidazol-2-amine, CATECHOL, Phosphatidylinositol 3-kinase regulatory subunit alpha, ... Authors: Gabelli, S.B, Vogelstein, B, Miller, M.S, Amzel, L.M. Deposit date: 2016-08-08 Release date: 2017-02-15 Last modified: 2024-11-13 Method: X-RAY DIFFRACTION (3.11 Å) Cite: Identification of allosteric binding sites for PI3K alpha oncogenic mutant specific inhibitor design. Bioorg. Med. Chem., 25, 2017
与片段5和21结合的PI3Kα（PI3K alpha）晶体结构 描述项：1H-苯并咪唑-2-胺、儿茶酚、磷脂酰肌醇3-激酶调节亚基α（Phosphatidylinositol 3-kinase regulatory subunit alpha），…… 作者：Gabelli S.B.、Vogelstein B.、Miller M.S.、Amzel L.M. 保藏日期：2016-08-08 发布日期：2017-02-15 最后修改日期：2024-11-13 实验方法：X射线衍射（3.11埃） 引用文献：PI3Kα致癌突变体变构结合位点的鉴定及特异性抑制剂设计. Bioorg. Med. Chem., 25, 2017
