The transcriptomic landscape of MAIT cell development in the thymus (C006 RNAseq data set). The transcriptomic landscape of MAIT cell development in the thymus (C006 RNAseq data set)

We report the transcriptomic landscape of MAIT cell development by examining thymic immature stage 1 and mature stage 3 MAIT cells from mouse thymus, and thymic immature stage 1, stage 2 mature stage 3 MAIT cells from human thymus using RNAseq. Overall design: We bulk-sorted (100 cell) each MAIT cell subset by flow cytometry and compared the differentially expressed genes (DEGs) between subsets. In addition, we single-cell sorted mouse mature MAIT cell subsets, performed single cell RNAseq comparison of mature thymic MAIT cell populations via clustering analysis to obtain in-depth information about the heterogeneity of functionally diverse mouse MAIT cells.