Transcriptomic profiling of human AML cell lines and primary AML samples

We sequenced mRNA from both cell lines and primary samples to investigate transcriptomic profiles of human AML cell lines and primary samples. We then performed gene expression profiling analysis using data obtained from RNA-seq of AML cell lines and primary samples that have sphingolipidomic characterization to identify transcriptional differences between two distinct sphingolipidomic subtypes in AML samples. Overall design: Comparative gene expression profiling analysis of RNA-seq data for human AML cell lines and primary samples that belonged to two distinct sphingolipidomic subtypes.